Antiviral activity of cationic amphiphilic drugs
نویسندگان
چکیده
منابع مشابه
Detachment of surface membrane invagination systems by cationic amphiphilic drugs
Several cell types develop extensive plasma membrane invaginations to serve a specific physiological function. For example, the megakaryocyte demarcation membrane system (DMS) provides a membrane reserve for platelet production and muscle transverse (T) tubules facilitate excitation:contraction coupling. Using impermeant fluorescent indicators, capacitance measurements and electron microscopy, ...
متن کاملCationic Amphiphilic Drugs Are Potent Inhibitors of Yeast Sporulation
Meiosis is a highly regulated developmental process that occurs in all eukaryotes that engage in sexual reproduction. Previous epidemiological work shows that male and female infertility is rising and environmental factors, including pollutants such as organic solvents, are thought to play a role in this phenomenon. To better understand how organic compounds interfere with meiotic development, ...
متن کاملDegradative transport of cationic amphiphilic drugs across phospholipid bilayers.
Drug molecules must cross multiple cell membrane barriers to reach their site of action. We present evidence that one of the largest classes of pharmaceutical drug molecules, the cationic amphiphilic drugs (CADs), does so via a catalytic reaction that degrades the phospholipid fabric of the membrane. We find that CADs partition rapidly to the polar-apolar region of the membrane. At physiologica...
متن کاملThe effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase.
1. Phosphatidate phosphohydrolase from the particle-free supernatant of rat liver was assayed by using emulsions of phosphatidate as substrate. 2. The inhibition of the phosphohydrolase by chlorpromazine was of a competitive type with respect to phosphatidate. The potency of various amphiphilic cationic drugs as inhibitors of this reaction was related to their partition coefficients into a phos...
متن کاملNon-Surface Activity of Cationic Amphiphilic Diblock Copolymers
Cationic amphiphilic diblock copolymers containing quaternized poly (2vinylpyridine) chain as a hydrophilic segment (PIp-b-PNMe2VP) were synthesized by living anionic polymerization. By IR measurement, we confirmed the quaternization of the polymer (PIp-b-PNMe2VP), and determined the degree of quaternization by conductometric titration. The surface tension experiment showed that the polymers ar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Review of Anti-infective Therapy
سال: 2017
ISSN: 1478-7210,1744-8336
DOI: 10.1080/14787210.2017.1305888